EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

ISOLATION AND EVALUATION OF HIBISCUS ROSA- SINENSIS LEAF MUCILAGE AS SUPERDISINTEGRANT

Rajni Bala, *Reecha Madaan, Vibhu, Aneesh and Dr. Sandeep Arora

ABSTRACT

Natural polymers remain attractive primarily because they are natural products of plants, readily available, inexpensive, and capable of multitude of chemical modification. Leaves of Hibiscus rosa- sinensis Linn (family: Malvaceae) contains high proportion of mucilage which can be used as additives in pharmaceutical formulations. The objective of the study is to extract mucilage from the leaves Hibiscus rosa-sinensis and examine the disintegrant property of the dried mucilage to assess its functionality as a pharmaceutical excipient.The Present work was carried out to study the disintergant property of Hibiscus rosa-sinensis mucilage using imipramine as a model drug. The present work was carried out to develop fast dissolving tablet of Imipramine using natural disintegrant isolated from Hibiscus rosasinensis leaves and its efficiency was compared with synthetic superdisintegrant like crosspovidone. Hibiscus rosasinensismucilage was isolated and characterised for its identification by chemical test and micrometric properties. Fast dissolving tablets of Imipramine were formulated by direct compression method using Hibiscus rosa-sinensis mucilage (2-8% w/w), Avicel PH 102 as diluents, mannitol to enhance mouth feel and compressibility, and aspartame as sweetener. The formulated tablets were evaluated for their pre and post compression parameters like tablet hardness, thickness, % friability, wetting time which was found to be in permissible limits. The in vitro disintegration time of tablet formulations containing 6% of mucilage was found to be 24 sec and that of tablet containing 4% of crosspovidone was 42secs. Based upon in vitro disintegration time in vitro drug release studies were carried out in phosphate buffer p H 6.8 which showed 100% drug release in 12 minutes of F3 formulation containing 6% of mucilage. Stability studies performed on F3 formulation indicated that the prepared tablets remain stable for the period of 90 days and showed no change in in vitro drug release pattern.

Keywords: Imipramine, Hibiscus rosa-sinensis, superdisintegrant, mucilage, Fast dissolving tablet.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )