NANOSUSPENSION: A NOVEL DRUG DELIVERY

Shweta Manoj Dhule*, T. Dhanalaxmi, M. Jyothi, U. Satish and P. Raviteja

ABSTRACT

Nanosuspension is an attractive and promising choice to break these problems. Nanosuspension consists of the poorly water-soluble medicine without any matrix material suspended in dispersion. Preparation of Nanosuspension is simple and applicable to all medicines that are water insoluble. A Nanosuspension not only solves the problems of poor solubility and bioavailability, but also alters the pharmacokinetics of medicine and therefore improves medicine safety and therapeutic effectiveness. Solubility is the pivotal factor for medicine effectiveness, independence of the route of administration. Large proportions of recently discovered medicines are water insoluble, and thus poorly bioavailable, contributing to vacated development effort. Preparation of Nanosuspension is simple and applicable to all medicines that are waterless and insoluble. Nanosuspensions are prepared by using a wet mill, high pressure homogenizer, emulsion solvent evaporation, melt emulsification method and supercritical fluid techniques. Nanosuspension can be prepared by using stabilizers, organic solvents and other additives similar as buffers, salts, polyols, and cryoprotectant. Nanosuspensions can be delivered by oral, parenteral, pulmonary and optical routes. Nanosuspensions can also be used for targeted drug delivery when incorporated in the optical inserts and mucoadhesive hydrogels.

Keywords: Nanosuspensions, Solubility enhancement, Characterization, Formulation, Surfactants.