FORMULATION AND EVALUATION OF ORAL FLOATING TABLET OF ETHAMSYLATE

Mohd. Shakir, Dr. Roshan Issarani, *Dr. Anjali Bhardwaj, Neha Parveen, Ashwani Gupta, Manu Bharti

ABSTRACT

The most important route of administering drug for systemic effects is the oral route of drug administration among all the route of drug delivery system. Floating tablet of ethamsylate formulated to increase gastric residence and thereby improve its therapeutic efficacy. The objective of this study was to formulate an oral floating tablet of ethamsylate using HPMC E15 LV, beeswax and ethyl cellulose. A fractional factorial design was applied systemically to assess the influence of 3 independent variables namely: amount of HPMC (X1), amount of beeswax(X2) and amount of ethyl cellulose(X3). EC and HPMC were used as floating and rate controlling polymers while beeswax used as hydrophobic meltable binders. From the present study it was observed that varying amount of the HPMC E15, beeswax and ethyl cellulose had significant influence on the lag time and % drug release of the prepared floating tablets. Tablets were prepared by melt granulation and evaluated by various parameters such as hardness, friability, weight variation test, In vitro buoyancy, drug content, in vitro drug release. Hardness was found to being the range from 4.3±0.13– 5.3±0.25kg/cm, The friability of prepared tablets was found in the range from 0.38%-0.72% which was satisfactory according to I.P.(0.5%-1%), The drug content varied from 93.75±0.87 to 104.62±0.38. All the prepared batches show it satisfactory floating time and in vitro drug release properties but F3can be considered to be the best optimised formulation because of least floating lag time and highest similarity factor.

Keywords: Ethamsylate, HPMC, floating drug delivery, beeswax, ethyl cellulose.