NANOSUSPENSION BASED SUBLINGUAL FILM OF FLUVOXAMINE MALEATE

Limbadiya Kavya* and Bansi Zalavadia

ABSTRACT

The primary objective of this study was to enhance the solubility of the BCS Class II drug, fluvoxamine maleate, by formulating it as a nanosuspension for incorporation into a sublingual film. The intention was to bypass hepatic first-pass metabolism, thereby improving bioavailability, ensuring faster onset of action, and increasing patient compliance. Nanosuspension were prepared using the Solvent-Antisolvent precipitation using PVPK-30 as a Stabilizer. Then solvent casting method was used to prepare sublingual film of theire suspension with HPMC E5 and Glycerol as polymer and plasticizer, respectively. The optimization of Sublingual film was done by 32 Full Factorial design. The independent variables were Concentration of film forming agents and plasticizer concentration. The optimized batch showed improved Disintegration time and cumulative drug release, and physical stability over time.

Keywords: Fluvoxamine Maleate, Nanosuspension, Sublingual Film, Full Factorial Design, Solvent- Antisolvent precipitation method, Solvent Casting method, Disintegration time, Depression.