EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

NEPHROPROTECTIVE ROLE OF NEERI-KFT (A POLYHERBAL FORMULATION) AGAINST GENTAMICIN INDUCED NEPHROTOXICITY IN EXPERIMENTAL RAT MODEL: A PRE-CLINICAL STUDY

Manish Kr. Tiwari, Sanchit Sharma, Ikshit Sharma, Parveen Kr. Goyal, Santosh Kr. Verma, Amit Barwal, Anil Kr. Sharma*

ABSTRACT

The present manuscript is mainly focused to experimentally elucidate the nephroprotective potential of Neeri-KFT (a polyherbal formulation for renal disorders hereinafter mentioned as NR-KFT) against aminoglycoside antibiotic Gentamicin (80mg/kg, i.p.) induced nephrotoxicity in albino Wistar rats. The nephroprotective potential of NR-KFT was also compared with ethanolic extract of Boerhaavia diffusa (Family: Nyctaginaceae), which is a vital constituent of NR-KFT and also individually used in renal disorders, to elucidate the synergism or additive effect of multiple herbal drugs present in NR-KFT. Since, many researchers mainly focused on antioxidants for nephroprotective potential therefore to elucidate that NR-KFT is not merely antioxidant, but exhibit nephroprotective potential, it was also compared with antioxidant Vitamin E. The experimental findings proved that NR-KFT possessed significant nephroprotective potential along with antioxidant activity; and the different herbal constituents present also potentiated the nephroprotective effect to produce wholesome better effect of correcting altered renal architecture and improving renal physiology. Conclusively, the NR-KFT showed significant nephroprotective potential in these pre-clinical studies.

Keywords: Neeri-KFT, Nephrotoxicity, Gentamicin, Nephroprotective, Boerhaavia diffusa, Vitamin E.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )