EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

HEPATOPROTECTIVE POTENTIAL OF METHANOLIC LEAF EXTRACT OF TRICHURIELLA MONSONIAE AGAINST PARACETAMOL INDUCED HEPATOTOXICITY IN RATS

*A. Rajani and A. Jaswanth

ABSTRACT

The present study, the methanol extract of Trichuriella monsoniae leaf was evaluated for their protective effects on paracetamol-induced liver damage in Wistar albino rats. Serum biochemical parameters viz. aspartate aminotransferase (AST), alanine transaminases (ALT), alkaline phosphatase (ALP), total protein (TP), bilirubin, cholesterol, albumin (ALB), lactae dehydrogenase (LDH), triglycerides (TG); and liver biochemical parameters such as reduced glutathione (GSH) content and catalase (CAT) and superoxide dismutase (SOD) activities were evaluated. Paracetamol (500mg/kg) induces hepatotoxicity and enhances the ALT, AST, ALP, liver weight and reduces total proteins. Treatment with Methanolic leaf extract of Trichuriella monsoniae (400 mg/kg) has brought back the altered levels of biochemical markers significantly to the near normal levels. The results were supported by histopathological studies of liver tissue. Phytochemical analysis of Trichuriella monsoniae indicated the presence of alkaloids, phenolics, saponins, flavonoids and polysaccharides. The study concluded that, the hepatoprotective potential may be attributed to the presence of flavonoids.

Keywords: Trichuriella monsoniae, Biochemical markers, Hepatoprotective & Hepatotoxicity, Paracetamol, Methanolic leaf extract.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )