FORMULATION AND DEVELOPMENT OF MICROSPONGE-LOADED ORAL FORMULATION CONTAINING NON-STEROIDAL ANTI-INFLAMMATORY DRUG

Deepthi Mathew*, Dr. Sunbee Prakash, Dr. Santhosh M. Mathews and Dr. I. John Wesley

ABSTRACT

Microsponges are porous, polymeric microspheres that are used chiefly for topical and recently, oral administration. Ketoprofen was used as a model drug for systemic drug elivery of microsponges in the study. Ketoprofen microsponges were prepared by the quasi-emulsion solvent diffusion method with Eudragit RS 100, and afterwards, tablets of microsponges were prepared by the direct compression method. Microsponges have shown a better compressibility for tabletting when compared with the other microparticulate systems or the physical mixture of the drug and the polymer. Results indicated that microsponge compressibility was much improved over the physical mixture of the drug and polymer, and owing to the plastic deformation of the sponge-like structure, microsponges produce mechanically strong tablets.

Keywords: Nonsteroidal antiinflammatory drugs, microsponges, oral formulation, Quasi emulsion solvent diffusion method.