EFFECT OF INHIBIN A AND RELATIONSHIP WITH OF SEX HORMONES IN WOMEN WITH PREECLAMPSIA VESTING SABHA INFERTILITY TREATMENT CENTER

Dr. Ibrahim Azzagah, Dr. Abdelhakim Milad Alwefa, Dr. Najat Amara Mohamed*

ABSTRACT

Background: Preeclampsia is a serious pregnancy complication affecting 5–8% of pregnancies and remains one of the leading causes of maternal and perinatal morbidity and mortality. Although its exact pathophysiology remains unclear, abnormal placental function and endothelial dysfunction are believed to play key roles. Inhibin A, a glycoprotein hormone produced by the placenta, has been proposed as a potential biomarker for preeclampsia. Objective: To evaluate the levels of Inhibin A and its relationship with sex hormones (LH, FSH, and progesterone) in women with preeclampsia. Materials and Methods: A case-control study was conducted at Sabha Infertility Treatment Center. It included 45 women in their third trimester: 30 with preeclampsia and 15 with normotensive pregnancies. Serum levels of Inhibin A were measured using ELISA, while LH, FSH, and progesterone were analyzed via chemiluminescence. Blood pressure and clinical data were also recorded. Data analysis was performed using SPSS v26, with significance set at p < 0.05. Results: Inhibin A levels were significantly higher in the preeclampsia group (1265.21 ± 101.24 ng/L) compared to the control group (444.38 ± 47.03 ng/L, p = 0.00). No significant differences were observed in LH, FSH, or progesterone levels. Inhibin A showed a positive correlation with systolic blood pressure (r = 0.54, p = 0.01) and mean blood pressure (r = 0.35, p = 0.03), but not with diastolic pressure or sex hormones. Conclusion: Elevated Inhibin A may be associated with the pathophysiology and severity of preeclampsia and could serve as a potential marker for disease assessment.

Keywords: Preeclampsia – inhibin A – pregnancy.