SPANLASTICS AS A PROMISING VEHICLE FOR NOVEL DRUG DELIVERY A REVIEW

Vanditha*, Krishnananda Kamath K Vindya V. S and A. R. Shabaraya

ABSTRACT

The aim of Novel drug delivery is to accomplish a predetermined drug action rate while simultaneously
maintaining a desired drug level in the body and limiting adverse effects. Vesicular drug delivery systems offer
significant advantages by overcoming the obstacles associated with traditional dosage forms. Therefore, Novel
systems like liposomes, nanoparticles, nano emulsions and nanosuspensions are being developed to improve drug
delivery efficiently. As a development in drug delivery systems, a new system known as Spanlastics which has
lesser side effects, was released in 2011. The Spanlastics are a new type of elastic vesicular Nano carrier that are
based on surfactants and are composed of spans and edge activators. This Nano vesicular system is elastic a nd
deformable, which entraps the drug in the core cavity as bilayer. These are composed of surfactants and
encapsulated by aqueous media. Spanlastics are chemically stable and offers targeted delivery and regulated release
and improve drug availability at the desired site. They have improved various short comings of the standard dosage
form, including providing targeting and controlled release of natural medicinal components, as well as other
benefits. They solve a variety of issues that are associated with the conventional dosage form by delivering the
active pharmaceutical components in a targeted manner and regulating the rate at which they are released.
Spanlastics have discovered a wide range of applications via different routes of administration. Their applications
through various routes of administration in a variety of diseases for a variety of drugs have been discussed. The
purpose of this review is to highlight the application of Spanlastics.

Keywords: Spanlastics, controlled release, targeted del ivery, applications.