FOUR SULFONAMIDE AGENTS HAVING PROPERTIES SUITABLE FOR TREATMENT OF DERMAL STAPHYLOCOCCUS AUREUS INFECTIONS

Ronald Bartzatt*

ABSTRACT

The most common bacterial pathogen associated with dermal infections across the world is Staphylococcus aureus. Up to 90% of all dermal bacterial events in the Northern Hemisphere are due to Staphylococcus aureus (S. aureus). This study presents four sulfonamide agents that have been shown to substantially inhibit the growth of S. aureus and possess favorable drug-likeness by way of having zero violations of the Rule of 5, which is an excellent indicator of drug like properties. All four sulfonamide agents showed greater that 30% inhibition of S. aureus at concentrations as low as 50 micrograms per milliliter. In addition, their molecular properties of molecular weight, polar surface area, and Log P are within the parameters of favorable drug-likeness. The dermal permeability constant, Kp, has been determined for each agent, for further comparison. Numerical values of Kp are expressed in centimeters per hour (cm/hour) and allow the estimation of dermal penetration based on measurement of time. The estimated dermal penetration of each agent over 1, 2, 3, 4, up to 10 hours, is shown graphically for comparison. The use of sulfonamide agents for the treatment of S. aureus dermal infections appears to have substantial efficacy.

Keywords: Staphylococcus aureus, sulfonamide, antibacterial.