A RETROSPECTIVE COMPARATIVE STUDY AND EVALUATION OF TUMOR BURDEN IN CONVENTIONAL VERSUS TRADITIONAL ANTI-NEOPLASTIC DRUGS

Dr. Mohd Minaz Pasha*, Dr. Fatema Arshi Saima, Dr. Shaik Fabiha Eestisam, Dr. Syed Mohammed Kazim

ABSTRACT

Background information: Cancer is a disease distinguished by uncontrollable or abnormal growth of cells resulting in the formation of malignant or benign tumors and suppressing the immune system, thereby deteriorating the quality of life of the host. The most common cause of mortality worldwide is “Cancer”, with an incidence of about 10 million deaths every year. India estimates about 14 61,427 cases roughly 100.4 per 100,000. With the increasing number of cancer cases, there is an advancement in its treatment as well. As the advancement in the treatment is seen, we also witness the serious side effects and ADRs connected with them, which are sometimes fatal to the patient. Therefore, it is necessary to have a rough idea about which drugs, either the traditional or the conventional, pose lesser side effects and are better choices for treating Cancer and improving a patient‟s quality of life. Aim: This study aims to compare the effectiveness of two drug classes for treating different types of cancer while assessing the tumor burden. The goal is to gain in-depth knowledge of the diseases and provide patients with effective treatment options. Objective: In this investigation, the patient with cancer will be extensively examined. To learn in-depth about the relevant illness and their condition. Demonstrating the patient's examination reports and the parameters with which we are going to assist the information already stored in the record room is going to be used in the thesis The treatment of cancer and the use of anti-neoplastic drugs should be evaluated. Method: A retrospective observational study evaluated the drugs to treat carcinoma in the Oncology department. Study period: The study was carried out for 6 months in Care hospital. Study population: The sample size consisted of 60-100 patients who qualified for the inclusion criteria for the study. Results: According to the study we analyzed 60 cases of Cancer patients out of which 34 cases were male and 26 were female between the age group of 9-80 years and the Cancer incidence rate in females was higher than in the male population. Some of them received the T drugs and few received C drugs, while the treatment cycle. Varied from 4-18. After a thorough investigation we found that both types of drugs were employed to treat Cancer and both of them were effective but the T drugs have much superior outcomes than the C drugs. Most Oncologists still prescribe the T drugs as before because of their fewer side effects, cost potency, and affordability by the patients. Conclusion: From the study, we can conclude that the prescribing pattern of the physicians still includes Traditional drugs such as Paclitaxel, Rituximab, Cisplatin, Carboplatin, 5FU, Zolendronic acid, and sometimes alongside other drugs. We found that traditional drugs had fewer side effects and were affordable to the patients. Conventional drugs were also used but not as often as the T drugs. In the coming years, we might see the increasing use of C drugs if they show lesser side effects with cost affordability. Another finding in the study that we came across was the patients with the blood group A+ were prone to Cancer in the 6 months, although this doesn‟t prove that the patients who belong to this blood group acquire Cancer commonly than the other blood group.

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