A REVIEW ON SOLID LIPID NANOPARTICLE

Abdul Wadood Ansari, Abhishek Yadav Ashish Kumar Yadav, Arti and Sapana Yadav

ABSTRACT

The most advanced nanotechnology formulations are solid lipid nanoparticles (SLN), which have several uses in a variety of domains, i ncluding drug delivery, clinical medicine, research, and other diverse disciplines. SLN are spherical, nanometre sized particles that are submerged in water or an aqueous surfactant solution while being treated with hydrophilic or lipophilic drugs. Various biodegradable and bio acceptable polymers that can also circumvent the harmful effects of conventional drug carrier systems should be used to improve the solubility and bioavailability of poorly soluble medications. Lipid nanoparticles present a chance to create novel treatments because of their special size dependent characteristics. Drug delivery presents a new concept that can be used for drug targeting through the ability to conjugate pharmaceutical to nano carriers. Solid lipid nanoparticles have ther efore drawn a lot of interest from researchers due to their significant potential for achieving the goal of regulated and site specific medication delivery. Lipids that are physiologically friendly are used to create solid lipid nanoparticles, or SLNs. The y are essential for the delivery of hydrophobic medications, which make up over 40% of all authorized medications Drug delivery methods based on nanotechnology can be divided into three categories based on their structural and chemical makeup: lipid based NPs, polymeric NPs, and inorganic NPs. Particular focus is placed on the relationship between drug incorporation and the complexity of SLN dispersions, which includes the physical state of the lipid (supercooled melts, various lipid modifications) and the presence of alternative colloidal structures (liposomes, micelles, drug nanosuspensions, mixed micelles, liquid crystals).

Keywords: Solid lipid nano particle, Nano structured lipid carriers, drug delivery.