FORMULATION AND EVALUATION OF DOXYLAMINE RAPID DISSOLVING TABLETS

Harish Kumar Singh* and Ashish Manigauha

ABSTRACT

Histamine H1 antagonists like doxylamine have strong sedative effects. Additionally, it has hypnotic, allergy, and antiemetic effects. Doxylamine succinate is a popular antihistaminic used to treat and prevent nausea and vomiting. It comes in the form of tablets that dissolve swiftly. The idea of fast-dissolving drug administration was born by providing the patient with a more traditional way to take their prescription. Doxylamine succinate-containing fast-dissolving tablets were produced using the direct compression method. Weight variation, hardness, friability, disintegration time, drug content, wetting time, and short-term stability studies were among the evaluation criteria for the manufactured fast-dissolving tablets. It was discovered that all of the formulations' percentage weight fluctuation and drug content homogeneity fell within the permitted limit. Friability and hardness, two evaluation measures, demonstrated that every formulation's tablet had good mechanical resistance.

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