REVIEW ON FORMULATION & EVALUATION METHODS OF INSITU SOLID LIPID NANOPARTICLES GEL DOSAGE FORMS

Erla Naga Chandrika* and Chennu M. M. Prasada Rao

ABSTRACT

This review discusses contemporary research on solid lipid nanoparticles (SLNs) for encapsulation and delivery of active and antioxidant compounds, encompassing various synthesis techniques and applications across multiple fields. The development of SLNs begins with the choice of solid lipid matrices, emulsifiers/surfactants, and types of active compounds or antioxidants, alongside synthesis methods and their respective applications. The lipid type influences crystal morphology, active compound release kinetics, and encapsulation efficacy. Various fabrication methods for SLNs can encapsulate both hydrophilic and hydrophobic antioxidants, each possessing distinct advantages and drawbacks. The design of fabrication, which entails selecting lipid matrices, surfactants, and fabrication techniques, critically influences SLN characteristics. High-shear homogenization paired with ultrasonication emerges as the preferred method due to its simplicity and efficacy. A well-conceived fabrication design yields SLNs that effectively stabilize active compounds and antioxidants, rendering them suitable for diverse applications.

Keywords: Insitu Gels, Solid Nano Particles, Solvent evaporation method, High Shier homogenisation.