A COMPREHENSIVE REVIEW: CHARACTERIZATION AND EVALUATION OF GELLIFIED EMULSION

Mayur S. Upade, Vijayananda K. Khadkutkar*, Maithili S. Kamble, Nivrutti A. Kotsulwar, Amrapali V. Rajput

ABSTRACT

Emulgel represents an innovative topical drug delivery system that merges the advantages of emulsions and gels. It enhances drug absorption, particularly for hydrophobic drugs, by improving solubility, stability, and penetration through the skin. The increasing demand for patient-friendly and effective drug delivery has led to the evolution of emulgels, which offer better spreadability, prolonged retention, and controlled drug release. These formulations incorporate emulsifiers, gelling agents, penetration enhancers, and oils to optimize drug delivery. Compared to conventional topical formulations such as ointments and creams, emulgels provide a non-greasy, easy-to-apply alternative with improved bioavailability. This review explores various aspects of emulgel formulation, including essential components, preparation techniques, drug release mechanisms, and evaluation parameters. The role of penetration enhancers in boosting therapeutic effectiveness is also discussed. Recent advancements in nanotechnology, bioadhesive polymers, and smart drug delivery systems have further enhanced emulgel formulations, making them suitable for various therapeutic applications, including anti-inflammatory, antifungal, and cosmetic treatments. While emulgels present numerous advantages, challenges such as formulation stability and drug release optimization require further research. With ongoing advancements, emulgels hold significant potential for improving topical drug delivery.

Keywords: Emulgel, Topical Drug Delivery, Hydrophobic Drugs, Skin Penetration, Nanoemulgel, Controlled Release, Skin Barriers, Physiological Barriers, etc.