PREVALENCE AND CHARACTERISTICS OF COMORBID CONDITIONS IN PATIENTS WITH CARDIOVASCULAR DISEASES

Urinov O. U.*, Fozilov Kh. G., Abidova D. E., and Boboev R. R.

ABSTRACT

Objective:
To determine the prevalence, structure, and clinical characteristics of comorbid conditions in patients
with cardiovascular diseases (CVD) in order to optimize diagnostic and treatment strategies. Mater ials and
Methods: A prospective cohort study was conducted among 1,220 patients (705 men [57.8%], 515 women
[42.2%]) at the Republican Specialized Scientific Practical Medical Center of Cardiology (Tashkent). • Mean age:
62.01 ± 9.83 years (men: 60.50 ± 10 .04, women: 64.08 ± 9.14). • Age range: 18 to 90 years. • Inclusion criteria:
confirmed CVD (stable angina, hypertension, CHF) and comorbidities (T2DM, CKD, COPD, previous COVID
19), with informed consent. • Control group: 214 patients (17.5%) with isolate d CVD. • Study group: 1,006
patients (82.5%) with comorbidities. • Diagnoses were established according to clinical guidelines. Results •
Comorbidity was found in 82.5% of patients with CVD. • The most frequent combinations were: o CVD + COPD
( esp ecially in age groups 45 59 (18.6%, p = 0.029) and 60 74 (18.7%, p = 0.026) o CVD + T2DM
(15.2% in ages 45 59), declining to 10.2% in those over 75 o CVD + CKD peaked in ages 60 74 (13.8%, p =
0.048). Conclusion : Comorbid conditions in CVD patients demons trate clear age and sex differences. The
combinations of CVD with COPD and T2DM are most prevalent among middle aged and elderly individuals,
while CKD is more common in those aged 60 74. Men are more susceptible to CVD + COPD + CKD, whereas
women more oft en suffer from CVD + T2DM + CKD.

Keywords: Cardiovascular diseases, Comorbidity, Chronic obstructive pulmonary disease, Type 2 diabetes mellitus, Chronic kidney disease, Arterial hypertension.