MOLECULAR DOCKING AND ADMET EVALUATION OF HETEROCYCLIC COMPOUNDS AGAINST PARKINSON RELATED GENES

Ch. Anjaiah*, Abeer Airajuddin and K. Swathi

ABSTRACT

Parkinson’s disease (PD) is a neurodegenerative disorder effecting both motor and nonmotor activities with symptoms like tremors, rigidity, bradykinesia and postural instability. Unusual clum ps of the proteins were found in the brain of people with PD, scientist assume that they are the deposits of protein alpha synuclein called Lewy bodies. The accumulation of alpha synuclein as clumps in the neurons in some part of the brain prevents neurotr ansmission there by affecting the functionality of brain. The actual cause of it is not known, attributing to various reasons like the environmental, genetic. If we consider genetics of the disease, literature talks that there are approximately 23 PARK gen es, of which we have considered PARK7, PINK, LRRK2 and their interactions with few active Thio heterocyclic compounds . And it is found that the LRRK2 and 4 aminophenyl) sulfanyl 4 hydroxychromen 2 one interacts well and holds a promising compound for furt her an invitro analysis.

Keywords: Parkinson disease, alpha synuclein, PARK, LRRK, PINK genes, h eterocyclic compounds.