EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

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Abstract

FORMULATION AND EVALUATION OF BUCCAL PATCHES OF TRAMODOL HYDROCHLORIDE

Verma Surender*, Gupta N. and Ashima

ABSTRACT

The goal of present investigation highlights the formulation and evaluation of mucoadhesive buccal patches of Tramadol hydrochloride. The mucoadhesive buccal patches of Tramadol hydrochloride were prepared by solvent casting technique using various combinations of polymers like HPMC E15, Carbopol 934, Carboxy Methyl Cellulose Sodium, Poly vinyl Alcohol and PVP K30. In the present study, total nine formulations were subjected to various evaluation parameters. Based on the evaluation results, it was concluded that drug content uniformity was varied between 75.5% (C5) and 98.6% (B2). Batch B showed higher drug loading as compared to Batch A and Batch C. Swelling was found to be greatest in batch B, followed by batch C and batch A respectively. Swelling increased with increase in concentrations of PVP, PVA, HPMC and Na CMC but was found to be inversely proportional to concentrations of Carbopol. It was also evaluated from the results that maximum in-vitro release was 94.07% (A9) over a period of 120 minutes for Batch A. For Batch B maximum release was evaluated to be 93.75% (B5) while for Batch C, it was found to be 98.3% (C4) after 120 minutes.

Keywords: Buccal patch, solvent casting technique, in-vitro release, swelling index, Tramadol Hydrochloride.


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