FABRICATION AND EVALUATION OF ANTI DIABETIC POLYHERBAL TABLETS

Shivangi Verma, Muskan, Ritika, Naveen Shukla, Mahesh Chand, Avneet Gupta, Deepak Prashar* and Vivek Kumar

ABSTRACT

Medicinal plants have played a crucial role in human civilization by providing essential resources, including medicines, for thousands of years. Their rich contents of bioactive secondary metabolites, such as alkaloids, glycosides, tannins, and lignans, contributes to various therapeutic properties, including anti-inflammatory, antioxidant, and antidiabetic effects. Given the increasing prevalence of diabetes mellitus and the side effects of synthetic drugs, there is growing interest in plant-based treatments. The study investigates the potential of six medicinal plants Trigonella foenum-graecum (Fenugreek), Moringa oleifera (Moringa), Nigella sativa (Black seed), Linum usitatissimum (Flaxseed), Cinnamomum zeylanicum (Cinnamon), and Macrotyloma uniflorum (Horse gram) for their antidiabetic properties. The research involves the collection, freeze-drying, and formulation of these plant extracts into a polyherbal tablet using methanolic extracts. Pre-formulation studies, including bulk density, tapped density, angle of repose, Carr’s index, and Hausner’s ratio were conducted to evaluate powder flow properties. Additionally, formulated tablets were subjected to quality assessment tests such as weight variation, friability, and disintegration time. The aim of the study is to contribute the growing body of evidence supporting the integration of medicinal plants into modern healthcare systems for diabetes management.

Keywords: Medicinal plants, Bioactive compounds, Antidiabetic properties, Pre-formulation studies, Polyherbal tablet, Diabetes.