SYNTHESIS AND EVALUATION OF NEW SUBSTITUTED N- (NAPHTHALEN-1-YLMETHYL)-2-OXO-2H-CHROMENE-3- CARBOXAMIDE DERIVATIVES AS ANTIMICROBIAL AGENTS

S. Sowmya Sri, D. Kumara Swamy*, Guduru Sai Krishna

ABSTRACT

Naphthalene structure consists of a fused pair of
benzene rings. 6 Substituted Naphthalene 2 carboxamide
derivatives (R=Br, CF 3 ) are found to be most potent antimicrobial, antitubercular agents. Numerou s biological
activities have been attributed to simple coumarins as well as pyranocoumarins, furocoumarins and analogues, e.g.
antimicrobial, antiviral, anticancer, enzymes inhibition, anti inflammatory, antioxidant, and central nervous system
activities. Coumarin derivatives have also been used as anticoagulants and also exhibit anti HIV and anti
tuberculosis (anti TB) activities. The synthesized compounds are purified by column chromatography and
characterized by analytical and spectral data (IR, 1H NMR a nd Mass). The synthesized compounds were evaluated
for antibacterial and antifungal activities.

Keywords: Diethyl Malonate, Triethyl amine, Coumarins, Antibacterial agents, Anti fungal agents.