EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

DIABETIC NEUROPATHY: OXIDATIVE STRESS AND NEUROINFLAMMATION

*Monalisa Debnath and Dr. Shruti Agrawal

ABSTRACT

Diabetic neuropathy associated microvascular complications are the most painful, disabling and fatal outcomes with an aetiology of oxidative stress and neuroinflammation; acting as pathophysiological triggers damaging the peripheral nerves and brain cells. It progresses with decreased nerve functionality and nerve blood perfusion that may result in permanent neuronal damage. The clinical manifestations include numbness, burning, tingling sensation and intractable pain. Neuroinflammation initiates pathogenesis resulting in various brain diseases, including not only acute but also neurodegenerative mental disorders. Numerous epidemiological studies have documented an increase in plasma levels of inflammatory markers like CRP, IL-6 and TNF-α along with many other molecules like transforming growth factor-β (TGF-β), MCP1 or LP-PLA2 among patients with metabolic syndromes. Some of the major pathways that play a crucial role in the progression of diabetic neuropathy include polyol pathway, advanced glycation end products, altered activity of (Na⁺-K⁺)ATPase, poly-ADP ribose polymerase (PARP) over-activation and cyclo-oxygenase-2 activation. Nerve cells are prone towards hyperglycaemic injury as neuronal glucose uptake is based on external glucose concentration that is found to be 4-5 folds higher among the diabetic subjects. Drugs like chemical chaperons-trimethylamine oxide and 4- phenyl butyric; peroxynitrite decomposition catalysts, PARP inhibitors; and antioxidants like 𝛼-lipoic acid and N-acetyl cysteine have been found to target oxidative stress inflammatory pathways thus improving the sensorimotor and functional deficits associated with diabetic neuropathy. Still, a lot of work is warranted to further elucidate the cross talk of oxidative stress, mitochondrial dysfunction, and inflammation in the pathophysiology of diabetic neuropathy.

Keywords: Diabetic neuropathy, neuroinflammation, neuronal damage, microvascular complications.


[Full Text Article]

INDEXING

NEWS & UPDATION

  • New Issue Published

    Its Our pleasure to inform you that, EJPMR 1 November 2021 Issue has been Published, Kindly check it on http://www.ejpmr.com/home/current_issues

  • EJPMR: NOVEMBER ISSUE PUBLISHED

    NOVEMBER Issue has been successfully launched on 1 November 2021.

  • EJPMR New Impact Factor

    Its our Pleasure to Inform you that EJPMR Impact Factor has been increased from  5.804 to 6.222, due to high quality Publication at International Level

  • Index Copernicus Value

    EJPMR Received Index Copernicus Value 79.57, due to High Quality Publication in EJPMR at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Article are invited for publication in EJPMR Coming Issue

Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )