ASSOCIATION BETWEEN AORTIC DISSECTION WITH CONCOMITANT CORONARY ARTERY DISEASE AND HEREDITARY CONNECTIVE TISSUE DISORDER: A META-ANALYSIS

Mohamed Nor Abubakara, Zhirong Lina, Shenghui Bib, Zhiye Wua and Yanbin Caia,*

ABSTRACT

Background: Aortic dissection is more common in individual with high blood pressure and atherosclerosis but most people with hypertension or atherosclerosis do not have dissection. Our aim is to identifying the association between aortic dissection and hereditary connective tissue disorders, as well as overlapping with genetic disorders linked to coronary artery disease. Methodology: We used databases based on PubMed, EMBASE and Scopus to cover almost all publications from 2000 to 2024. In the quality analysis, we created a number of tools, such as The Newcastle-Ottawa Scale and checklists are utilized to assess the validity of certain observational studies. Result: Based on four studies, aortic dissection occurrences were revealed in 414 participants, with 251 individuals having HCTD and 163 patients without HCTD (OR = 2.35, CL = 1.67–3.33, p < 0.0001). As shown by I2 = 31% and P = 0.22, the study results exhibit no detectable heterogeneity, the findings demonstrated a strong association between HCTD and an elevated risk of AD when compared to non-HCTD. Our findings indicate that of the twelve identified CAD risk genes, genetic risk factors associated with aortic dissection elevate the probability of developing coronary artery disease. SMAD3, APOB, and COL4A1 exhibited an overlap in both aortic dissection and coronary artery disease. Conclusion: This study establishes an outline for identifying the high-risk population for HCTD-associated AD and CAD, and helps to formulate preventive and therapeutic strategies and further investigation of genetic mechanisms particular observing the TGF-B pathway linked to AD may optimize risk assessment in the future.

Keywords: Aortic dissection. Hereditary connective tissue disorder. Coronary artery disease.