EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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Abstract

SYNTHESIS OF NEW HETEROCYCLIC COMPOUNDS DERIVED FROM BIS (5-AMINO-1,3,4-THIADIAZOLE- 2-YL) DISULFIDE

Redha I. H. AL-Bayati, *Sajida Munadi Th. AL-Suraify, Raad M. Al-Saedi

ABSTRACT

In present study, 14 compounds derived from 2-amino-5-mercapto-1,3,4-thiadiazol were synthesized, The first route included oxidation above compound by hydrogen peroxide to disulfide ( or dithio ) compound (1). The reaction of compound (1) with sodium nitrite in concentration hydrochloric acid organized diazonium salt (2) which interrelate with o-hydroxy aceto phenone and salicylic aldehyde to produce azo derivatives (3,4), respectively . Adsorbing of carbonyl groups of azo derivatives (3,4) with p-methyl aniline donating schiff bases (5,10). Then, when the last cyclized with mercapto acetic acid generate thiazolidine-4-one derivatives (9,12). While adsorbing of compounds (3,4) with o-bromo benzaldehyde and DHA by claisen-schirnidt condensation formed chalchons (6,11) respectively. Cyclization of chalcones with malononitrile in attendance of piperidine gave compounds (8,14) . eventually, oxazine derivatives (7,13) were produced by reaction of chalcons with urea. Al synthesized compounds were describing by employ some spectroscopic assay such as UV, FTIR, 1HNMR and 13C-NMR.

Keywords: disulfide compounds, chalcone derivatives, schiff bases, azo compounds.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia