OVERVIEW OF AMISULPRIDE

Sayali Rajendra Khadake*

ABSTRACT

Amisulpride, sold under the brand names Solian and Barhemsys, It is a medication used in the treatment of schizophrenia, acute psychotic episodes, depression, and nausea and vomiting.
It is specifically used at lower doses intravenously to prevent and treat postoperative nausea and vomiting low doses by mouth to treat depression; at higher doses by mouth to treat psychosis.
It is usually classed with the atypical antipsychotics.
Chemically it is a benzamide and like other benzamide antipsychotics, such as sulpiride
it is associated with a high risk of elevating blood levels of the lactation hormone, prolactin thereby potentially causing the absence of the menstrual cycle, breast enlargement, even in males, breast milk secretion not related to breastfeeding, impaired fertility, impotence, breast pain, etc.), and a low risk, relative to the typical antipsychotics, of causing movement disorders. Amisulpride is believed to work by blocking, or antagonizing, the dopamine D2 receptor, reducing its signalling.
The effectiveness of amisulpride in treating dysthymia and the negative symptoms of schizophrenia is believed to stem from its blockade of the presynaptic dopamine D2 and D3 autoreceptors.

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