ACTIVATION OF COMPLEMENT SYSTEM ALTERNATE PATHWAY BY ANDROGRAPHIS PANICULATA, OCIMUM SANCTUM AND AZADIRACHTA INDICA
*Balaji P, Fathima N, Lakshyajit Kakati, Jaseer K.K, Uma Krithika S and Kannan K.
The effect of aqueous extracts of Andrographis paniculata (AEAP), Ocimum sanctum (AEOS) and Azadirachta indica (AEAI) on in vitro complement system alternate pathway (AP) activity was evaluated and compared with that of the known immunostimulant levamisole. The results suggest that there is a concentration dependent increase in the AP activity for levamisole, AEOS and AEAI. The activity exhibited by Andrographis paniculata was less than that of other herbs studied.
Keywords: Complement system, Alternate pathway, Haemolytic activity, Andrographis paniculata, Ocimum sanctum and Azadirachta indica.
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