EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

DRUG INDUCED HEPATOTOXICITY AFTER INDUCTION PHASE OF CHEMOTHERAPY IN ACUTE LYMPHOBLASTIC LEUKEMIC PATIENTS.

Abdul Sattar, *Aziza Khanam, Sidra Ibad and Ali Iftikhar

ABSTRACT

The present study includes 20 prediagnosed Acute lymphoblastic Leukemic (ALL) and 20 normal control children. The Biochemical parameters (Bilirubin, Alanine amino transferase, Alkaline phosphatase and gamma glutamyl transferase) and complete blood count were investigated in control and leukemic patients. It was found that there was no significant difference between serum level of Bilirubin, Alanine aminotransferase, Alkaline phosphatase in leukemic patients as compared to control normal subjects. The serum Gamma glutamyl transferase of leukemic patients was high as compared to control subjects. There was significant increase in the blood level of Bilirubin, Alanine aminotransferase, Alkaline phosphatase and γ – Glutamyl transferase in patients after chemotherapy (Vincristine, L – asparaginase, Daunomycin, and Methotrexate) as compared to patients before Therapy. There was significant decrease in the number of blast cells and an increase in the level of hemoglobin, RBC, PCV, MCV, and neutrophil in leukemic patients after chemotherapy as compared to patients before chemotherapy. Conclusion: The chemotherapy induced hepatotoxicity, is present in ALL patients.

Keywords: Acute Lymphoblastic Leukemia (ALL), Chemotherapy, Induction phase, Hepatotoxicity, Hematological disorder.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )