EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

FRACTAL DIMENSION: A NEW METHOD TO QUANTIFY INTESTINAL HEALING IN DIABETES

Erika Veruska Paiva Ortolan*, Carlos Antônio Caramori, Pedro Luiz Toledo de Arruda Lourenção, Simone Antunes Terra, Marcos Curcio Angelini and César Tadeu Spadella

ABSTRACT

Purpose: to investigate if experimental alloxanic diabetes could cause quantitative changes in intestinal anastomoses of the terminal ileum and distal colon in rats, as compared to controls, measured by fractal dimension. Method: 96 male Wistar rats weighing ±300 g were split into four groups, and were submitted to ileum and colon anastomoses after a 3 month pre op period of follow up: G1- control group with ileum anastomoses, G2- control group with colon anastomoses, G3-diabetic group with ileum anastomose and G4- diabetic group with colon anastomoses. After a three month post-op period, the animals were sacrificed on days 4, 14, 21 and 30, and fragments of the anastomoses were removed, and analyzed in the scanning electron microscope and the images obtained were used to calculate the fractal dimension of the anastomosis. Results: Ultrastructural analysis of the anastomoses revealed fewer wide collagen fibers that were narrower and disarranged, as compares to the control animals in all of the moments. The results of fractal dimension showed a tendency to higher complexity of the anastomosis in the diabetic animals, as compared to controls. Conclusion: experimental diabetes caused qualitative changes in scar tissue, seen at alterations in the structural arrangement of collagen fibers and a tendency to more complexity in fractal dimension.

Keywords: alloxan Diabetes, wound healing, surgical anastomosis, fractals.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )