HELICOBACTER PYLORI ERADICATION EXPERIENCE WITH SEQUENTIAL TREATMENT CONSIST OF ANTIBIOTICS USED IN CONVENTIONAL TRIPLE THERAPY

Serdar Olt*, Mustafa Erhan Altunöz and Selçuk Yaylac?

ABSTRACT

Helicobacter pylori eradication treatment protocols are constantly changing due to the antibiotic resistance and different rates of different combinations can be successful in different countries because of this resistance. In the light of recent studies, the sequential treatment modalities are now a prominent choice of treatment today due to high rates of eradication. In this study, the success rate of sequential treatment in Helicobacter pylori eradication was investigated in non-ulcer dyspepsia patients with positive Helicobacter pylori. 92 non-ulcer dyspepsia patients with positive Helicobacter pylori were included in the study. The presence of Helicobacter pylori was detected by histopathological examination of the biopsy specimen taken from the antrum and corpus. Our Helicobacter pylori eradication treatment protocol was 30 mg lansoprazole twice daily and 1 gram amoxicillin three times daily were given to the patients in the first 7 days, in the second 7 days 30 mg lansoprazole twice daily, 500 mg clarithromycin twice daily and 1 gram amoxicillin twice daily. 6 weeks after the end of the treatment, all of the patients were re-evaluated for Helicobacter pylori eradication by the urea breath test. Eradication was considered to be successful in patients with negative urea breath test. In this present study the helicobacter pylori was eradicated in 89.1% of the patients. As a result, the method of nitroimidazole-free sequential treatment we applied in the H pylori eradication therapy was found to be a more successful method than the classic triple therapy in the primary treatment. Given the success rate of eradication, we suggest a sequential treatment that consists of the antibiotics used in classic therapy may be an important option in the first-line treatment.

Keywords: Helicobacter Pylori eradication, Conventional triple therapy, Sequential eradication treatment.