EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

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 ICV - 79.57

Abstract

HELICOBACTER PYLORI ERADICATION EXPERIENCE WITH SEQUENTIAL TREATMENT CONSIST OF ANTIBIOTICS USED IN CONVENTIONAL TRIPLE THERAPY

Serdar Olt*, Mustafa Erhan Altunöz and Selçuk Yaylac?

ABSTRACT

Helicobacter pylori eradication treatment protocols are constantly changing due to the antibiotic resistance and different rates of different combinations can be successful in different countries because of this resistance. In the light of recent studies, the sequential treatment modalities are now a prominent choice of treatment today due to high rates of eradication. In this study, the success rate of sequential treatment in Helicobacter pylori eradication was investigated in non-ulcer dyspepsia patients with positive Helicobacter pylori. 92 non-ulcer dyspepsia patients with positive Helicobacter pylori were included in the study. The presence of Helicobacter pylori was detected by histopathological examination of the biopsy specimen taken from the antrum and corpus. Our Helicobacter pylori eradication treatment protocol was 30 mg lansoprazole twice daily and 1 gram amoxicillin three times daily were given to the patients in the first 7 days, in the second 7 days 30 mg lansoprazole twice daily, 500 mg clarithromycin twice daily and 1 gram amoxicillin twice daily. 6 weeks after the end of the treatment, all of the patients were re-evaluated for Helicobacter pylori eradication by the urea breath test. Eradication was considered to be successful in patients with negative urea breath test. In this present study the helicobacter pylori was eradicated in 89.1% of the patients. As a result, the method of nitroimidazole-free sequential treatment we applied in the H pylori eradication therapy was found to be a more successful method than the classic triple therapy in the primary treatment. Given the success rate of eradication, we suggest a sequential treatment that consists of the antibiotics used in classic therapy may be an important option in the first-line treatment.

Keywords: Helicobacter Pylori eradication, Conventional triple therapy, Sequential eradication treatment.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia