EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

"HEPATOPROTECTIVE EFFECTS OF THE AQUEOUS EXTRACT OF CLOVE (SYZYGIUMAROMATICUM) AGAINST PARACETAMOL-INDUCED HEPATOTOXICITY AND OXIDATIVE STRESS IN RATS"

Mahdi M. Thuwaini, *Mohammed Abdul-Mounther and Hanaa S. Kadhem

ABSTRACT

Hepatoprotective activity of aqueous extract of clove (Syzygiumaromaticum) in albino rats was observed against controversial hepatotoxicity effects of paracetamol(PCM) induced liver toxicity in rats. Paracetamol was administered to induce hepatic damage in Wistar albino rats. 100 and 200 mg/kg doses of clove extract and were used as treatment groups. In present study, the effects of clove extract [100 mg per kg B.W. and 200 mg/kg.B.W.] as alone. On PCM-induced hepatotoxicity were examined. Rats were divided haphazardly into six groups containing 6 rats each. The control group received distal water (D.W.). Other groups were treated with PCM (600mg/kg) alone, (600mg/kg PCM + 100mg/kg clove extract), and (600mg/kg PCM + 200mg/kg extract) respectively for 4 weeks. The blood samples were analyzed for biochemical labels of hepatic injury and tissue samples were subjected for assessing of liver antioxidants and histopathological studies. Analysis of the treated rats with PCM (600 mg/kg) showed Paracetamol induced male rat hepatotoxicity represented by significant decline in the serum total albumin (P< 0.05). Conversely, the study declared significantly increment (P< 0.001), bilirubin, ALT, AST and ALP as shown in group2 (induction group) in compared with group1 (control group). While, simultaneous administration of clove aqueous extract (100mg/kg and 200mg/kg) with paracetamol, was displayed significantly attenuated the adverse changes in the serum total albumin, bilirubine, ALT IU/L, AST, and ALP. The histopathological examination in the liver of rats also encouraging that clove extract markedly diminished the toxicity of PCM and keeps the histoarchitecture of the liver tissue to near normal. Hence, the results postulate that clove extract acts as a potent hepatoprotective agent against PCM induced hepatotoxicity in rats.

Keywords: Hepatotoxicity, Syzygiumaromaticum, Wister rats, Paracetamol, Serum liver enzymes.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )