EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

EFFECT OF APITHERAPY ON THE PANCREAS & LIVER OF STREPTOZOTACIN INDUCED DIABETIC RATS. A BIOCHEMICAL AND HISTOLOGICAL STUDY

Sara Abdel Gawad, Heba Fikry*, Amira Ramadan Elmahdi, Mariam Maged Amin and Doaa Abd Elaziz

ABSTRACT

Objective: The main issue in management of diabetes mellitus (DM) is to control blood glucose level and lipid profile using medical agents including natural toxins. Bee venom (BV) which had been used to treat various diseases is of a great importance in this regard. So the aim of the work was to evaluate the therapeutic effects of honey BV (apitoxin) on blood glucose level, lipid profile as well as on the histological changes in pancreas and liver of Streptozotacin (STZ) induced diabetic rats. Design and methods: This study assessed serum glucose level, C.peptide, C- Reactive protein (CRP), triglyceride (TG) and total cholesterol in fifty adult male albino rats divided into four randomly groups: control, BV group , STZ induced diabetic group and BV treated group. Then they were sacrificed for pancreatic and liver biopsy. Results: Serum glucose, CRP, TG and total cholesterol levels was significantly decreased (Pï‚£ 0.05) in BV treated group in comparison with diabetic group. Moreover, BV treated group showed significant increase in serum C.peptide level and area percentage of anti-insulin antibodies in the pancreatic tissue (Pï‚£ 0.05) as well as restoration of normal histological structure of pancreatic cells and hepatocytes in comparison with diabetic group. Conclusion: Administration of BV improves blood glucose and lipid profile as well as histological features of the pancreas and liver in STZ induced diabetic rats, therefore it can be considered as a novel therapeutic agent for DM.

Keywords: Bee venom, Streptozotacin, Diabetes mellitus, Insulin.


[Full Text Article]

INDEXING

NEWS & UPDATION

  • New Issue Published

    Its Our pleasure to inform you that, EJPMR 1 April 2021 Issue has been Published, Kindly check it on http://www.ejpmr.com/home/current_issues

  • EJPMR: APRIL ISSUE PUBLISHED

    APRIL Issue has been successfully launched on 1 April 2021.

  • EJPMR New Impact Factor

    Its our Pleasure to Inform you that EJPMR Impact Factor has been increased from  5.804 to 6.222, due to high quality Publication at International Level

  • Index Copernicus Value

    EJPMR Received Index Copernicus Value 79.57, due to High Quality Publication in EJPMR at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Article are invited for publication in EJPMR Coming Issue

Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )