EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

GREEN SYNTHESIS, SPECTRAL CHARACTERIZATION AND BIOLOGICAL ACTIVITY OF NOVEL ACETYL PYRAZOLE DERIVATIVES

Ezhilarasi. M. R*, Prabha.B and Kulandhaivel.M

ABSTRACT

Compounds 1-acetyl-4, 5-dihydro-5-aryl-3-(thiophen-2yl)pyrazoles (5-8) have been synthesized by microwave followed by green chemistry principle and convectional method. The Microwave irradiation method is the best method over than conventional method. Because eco-friendly, less solvent, time saving and good yields compared to the conventional method. All the synthesized compounds are characterized by IR, Mass, 1H NMR, 13C NMR spectral studies and elemental analysis. Compounds are screened for bacterial activity against S.aureus and S.pyogenes (Gram positive) and P.aeroginosa and K.pneumoniae (Gram negative) strains and C.albicans is the fungal strains. The bromo substituted phenyl ring compound shows an excellent antibacterial activity against the bacterial strains and the methoxy group substituted compound shows the excellent antifungal activity against the fungal strains when compared with the standard drug Ciprofloxacin’s for both antifungal and antibacterial activity. The drug ability of the compounds was confirmed by Lipinski’s Rule (Rule 5).

Keywords: Microwave irradiation, Pyrazole, Hydrazine hydrate, Antimicrobial activity, Lipinski’s rule.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )