GREEN SYNTHESIS, SPECTRAL CHARACTERIZATION AND BIOLOGICAL ACTIVITY OF NOVEL ACETYL PYRAZOLE DERIVATIVES

Ezhilarasi. M. R*, Prabha.B and Kulandhaivel.M

ABSTRACT

Compounds 1-acetyl-4, 5-dihydro-5-aryl-3-(thiophen-2yl)pyrazoles (5-8) have been synthesized by microwave followed by green chemistry principle and convectional method. The Microwave irradiation method is the best method over than conventional method. Because eco-friendly, less solvent, time saving and good yields compared to the conventional method. All the synthesized compounds are characterized by IR, Mass, 1H NMR, 13C NMR spectral studies and elemental analysis. Compounds are screened for bacterial activity against S.aureus and S.pyogenes (Gram positive) and P.aeroginosa and K.pneumoniae (Gram negative) strains and C.albicans is the fungal strains. The bromo substituted phenyl ring compound shows an excellent antibacterial activity against the bacterial strains and the methoxy group substituted compound shows the excellent antifungal activity against the fungal strains when compared with the standard drug Ciprofloxacin’s for both antifungal and antibacterial activity. The drug ability of the compounds was confirmed by Lipinski’s Rule (Rule 5).

Keywords: Microwave irradiation, Pyrazole, Hydrazine hydrate, Antimicrobial activity, Lipinski’s rule.