EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

STUDIES IN DEVELOPMENT OF DASATINIB NANOFORMULATIONS

Dr. Rakesh P. Patel* and Nitish Thakker

ABSTRACT

Dasatinib (DST) is an anti-cancer drug having poor water solubility and high permeability. Low aqueous solubility and poor dissolution of DST results into poor and variable bioavailability. Its limited aqueous solubility and high lipophilicity limits the therapeutic outcome. The aim of present work was to increase solubility of DST which may increase the bioavailability. Nanoformulations of DST such as Nanoparticle, Solid Lipid Nanoparticle (SLNs) and Nanocrystals were prepared and evaluated for physicochemical characteristics. Finalised Nanoformulations were compared with respect to Solubility, In-Vitro drug release, In-Vitro cytotoxicity and Bioavailability study. From the physicochemical characterization and evaluation of all nanoformulations, it was observed that Polylactic-co-glycolic acid (PLGA) Nanoparticles prepared using solvent-anti solvent precipitation method has higher increment in the solubility compare to SLNs and Nanocrystal of DST. Cytotoxicity Study showed that PLGA Nanoparticles have higher bioavailability as well as higher % Cell inhibition. In a nutshell, Nanoformulation such as PLGA Nanoparticle is one of the promising approach to enhance the Bioavailability of DST.

Keywords: Dasatinib (DST), Nanoparticles, Solid Lipid Nanoparticles (SLNs), Nanocrystals, Bioavailability, Poly lactic-co-glycolic acid (PLGA).


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia