SYNTHESIS OF N’-SUBSTITUTED-N”-SUBSTITUTEDFORMAMIDINO-2-IMINO-4-THIOBIURATES
D. T. Tayade* and S. P. Ingole
The role of naturally available fruit juice in organic synthesis has attracted the interest of chemist, particularly from the view of green chemistry. Fruit juices act as a biocatalyst in different chemical transformation. Lemon fruit juice is extensively used for condensation reactions due to their powerful and selective natural acid biocatalytic property in organic synthesis and allows mild and highly selective transformation and synthesis in facile and environmentally friendly manner. Moreover, fruits are inexpensive and easily available in the market and its juice can be extracted easily which can be used as biocatalyst in the organic transformations. Hence one-pot three-component condensation of 1,3-diformamidinothiocarbamide with various aldehydes in presence of one drop of concentrated sulphuric acid was carried out in presence of lemon juice as a biocatalyst respectively to synthesize a novel series of N’-substituted-N”-substitutedformamidino-2-imino-4-thiobiurates, which is heither to unknown.
Keywords: thiocarbamide, various aldehyde, lemon juice.
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