PHARMACOLOGICAL INSIGHTS AND CLINICAL APPLICATIONS OF GLYCERYL TRINITRATE: A COMPREHENSIVE REVIEW

Manoj Kashyap, Chetan Kumar, Amrit Paul*, Tanmay Jit and Anil Sao

ABSTRACT

Glyceryl trinitrate (gtn), commonly referred to as nitroglycerin, has been a pivotal medicine in the management of cardiovascular illnesses, particularly for its vasodilatory properties. Initially identified for its explosive properties, GTN's clinical application emerged in the late 1800s, revolutionizing the treatment of angina pectoris. This comprehensive review delves into the pharmacological properties of gtn, including its mechanism of action, pharmacokinetics, and pharmacodynamics, with a focus on its cardiovascular packages. The evaluation also explores GTN’s medical importance in treating acute and continual cardiovascular conditions, inclusive of angina pectoris, acute heart failure, and hypertensive emergencies. Furthermore, the evaluation discusses off-label uses, as well as remedies for esophageal spasms and chronic anal fissures. Regardless of its extensive use, gtn provides demanding situations, including tolerance improvement and a short length of movement. Current studies highlight new capacity programs of gtn in heart failure with preserved ejection fraction (hfpef) and wound recovery, suggesting that gtn's role in medicine keeps conforming. The evaluation concludes by emphasising the significance of persisted studies and innovation in GTN therapy to optimise patient effects.

Keywords: Glyceryl trinitrate, nitroglycerin, angina pectoris, vasodilation, pharmacokinetics, pharmacodynamics, cardiovascular illnesses, tolerance, coronary heart failure, hypertensive emergencies, off-label uses, drug transport structures, personalised medicine,