SYNTHESIS, CHARACTERIZATION AND DETERMINATION OF ANTIMICROBIAL ACTIVITY OF NOVEL CHALCONES OF 3-ACETYL 4-HYDROXY-6-METHYL-2HPYRAN- 2-ONE
*Pottabathula Shyam Sundar and D. Gunasheela
In an effort to develop antimicrobial agents, a series of substituted 3- cinnamoyl-4- hydroxy-6-methyl-2-pyrones
were synthesized by base catalyzed condensation of 3-acetyl-4- hydroxy-6-methyl-2-oxa-2H-pyran (DHA) with
different aromatic or heteroaromatic aldehydes. The synthesized compounds were characterized by means of their
IR, 1HNMR, 13CNMR and Mass spectroscopic data. The synthesized compounds were tested for their
antibacterial and antifungal activities.
Keywords: Substituted 3-cinnamoyl-4-hydroxy-6-methyl-2-pyrones, Dehydroacetic acid, Antibacterial and antifungal activity.
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