CREATION AND ASSESSMENT OF CURCUMIN-EMBEDDED SUPPOSITORIES THROUGH THE MACERATION PROCESS

Subhasish Saha, Dr. Saumendu Deb Roy, Amrit Paul* and Vikas Kumar Roy

ABSTRACT

Suppositories provide a different way to administer medicine, especially for people who can't take oral prescriptions because of nausea, vomiting, or swallowing issues, or who have vaginal or rectal infections. Using a glycerol-gelatin basis, this research looks into the formulation and assessment of suppositories containing curcumin. Turmeric produces curcumin, a bioactive molecule known for its anti-inflammatory, antioxidant, and anticancer effects, but its poor bioavailability hinders its oral absorption. We used a glycerol-gelatin basis, known for its hydrophilic characteristics, to improve the solubility and release of curcumin at body temperature. We assessed numerous physicochemical characteristics of the prepared suppositories, including visual characterisation, weight fluctuation, hardness, melting point, disintegration, and dissolution. The suppositories successfully released curcumin due to their constant melting point, appropriate hardness, and homogenous weight. Tests on the formulation's capacity to distribute curcumin effectively via dissolution and disintegration provided further confirmation. According to the study, curcumin-based suppositories made with a glycerol-gelatin base could be a good way to improve curcumin's bioavailability and therapeutic efficacy for people who can't take it by mouth, especially in situations where its therapeutic properties can be used effectively.

Keywords: Suppositories, Rectal, Curcumin, Glycerol-gelatin, bioavailability, Anti-inflammatory, Anticancer.