EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 7.065

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Abstract

STERNAL INTRAOSSEOUS EPINEPHRINE ADMINISTRATION IN A HYPOVOLEMIC PEDIATRIC CARDIAC ARREST MODEL

Dr. Don Johnson*, Julie G. Hensler, Dawn Blouin, Young John Yauger, MAJ Benjamin C. Dixon and Joseph O’Sullivan

ABSTRACT

Introduction: The purposes were to compare return of spontaneous circulation (ROSC), the maximum concentration (Cmax), time to maximum concentration (Tmax), mean concentration (MC), and area under the curve (AUC) of epinephrine administered by the sternal intraosseous (SIO) route and the intravenous (IV) route. Procedures: Yorkshire (Sus scrofa) Swine weighing 20-30 kg representing 9-year-old children were randomly assigned to SIO (n = 9); IV (n = 7); CPR + defibrillation (CPR+defib) (n = 7); CPR-Only (n = 5) groups. Thirty-five percent of their blood volume was exsanguinated. Pigs were then placed in arrest for 2 min; CPR was started for 2 min; epinephrine 0.01 mg/kg was then administered to the SIO and IV groups. Blood samples were collected over 5 minutes. After sample collection, epinephrine was continued every 4 min, and defibrillation was performed every 2 mins. Results: The frequency of ROSC was significantly higher in the SIO (9 out of 9) group than the IV (5 out of 7); the CPR+defib (1 out of 7), and CPR-Only groups (0 out of 5) (p < 0.05). No significant difference occurred between the time to ROSC between the groups (p = 0.419). SIO had an 8.6 times greater chance of ROSC compared to the IV group. Overall, the IV group had higher MC over time, longer Tmax, and higher AUC than the SIO group (p < 0.05). Conclusion: The SIO group was highly effective and should be considered as a first-line intervention for pediatric hypovolemic patients in cardiac arrest.

Keywords: Pediatric CPR; Hypovolemic shock; Hemorrhage; Cardiac Arrest; Sternal Intraosseous Epinephrine.


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