A PROSPECTIVE OBSERVATIONAL STUDY ON CLINICAL SAFETY AND EFFICACY OF IMMUNOSUPPRESANTS USED IN THE LIVER TRANSPLANT RECIPIENTS

Kolloji Adarsh, Bollareddy Devendra Reddy, Mailaram Abhinay Goud, Neela Ojeswin, Dr. V. Anudeep,
Dr. Chandan Kumar K. N.

ABSTRACT

Background: Nearly eight thousand liver transplantation occurs every year. Within the first year following their transplant, recipients of deceased donor livers had a seven percent prevalence of allograft failure. Methodology: Our Research project was an observational study which includes 68 individuals to assess outcomes and safety of research of immunosuppressants used in liver transplantation. Results: According to our research effort, immunosuppressants were mostly administered and shown their efficacy in liver transplant patients by lowering rejection rates. Immunosuppressants were administered in triple regimens for 25.7% of the population and in dual medication regimens for 74.28% of patients. Conclusion: 70% of patients obtained an order for tacrolimus, 20% for cyclosporine, and 10% for mycophenolate mofetil, among other immunosuppressants. Mostly these drugs are given in the combination of TAC + CYC.

Keywords: A Prospective Observational Study, Clinical Safety, Immunosuppressants, Liver Transplant Recipients.