A LABORATORY STUDY OF BLOOD PLATELET DISTRIBUTION WIDTH (PDW) IN LARYNGEAL CANCER PATIENTS BEFORE AND AFTER SURGERY

Moayad Jalal Kheirbek*, Mostafa Ibrahim and Faisal Radwan

ABSTRACT

Laryngeal cancer constitutes 2% of diagnosed cancer cases and affects men more than women, with an incidence
rate of 100, 000/5. The aim of the research was to study changes in platelet distribution width (PDW) in patients
before and after surgery, and then compare these values with a control group. The research was conducted on all
patients who underwent laryngectomy in 2022 and 2023 from the Department of Otorhinolaryngology and Surgery
at Tishreen University Hospital in Lattakia, after obtaining informed consent, where a prospective study was
conducted, and the number of patients reached (30) patients. A research form was organized for the patients. The
results of the research showed that there were no significant changes in platelet distribution width (PDW) in
patients with laryngeal cancer one week after surgery compared to their values before surgery. Laryngeal cancer
patients had significantly higher PDW levels than healthy individuals, both before and after surgery. The study
recommends the importance of conducting more studies to confirm our results in larger groups of patients and
different and multiple time periods. The association of PDW with the general condition of patients should be
evaluated and factors that may affect their PDW should be investigated, such as the type of anesthesia, the type of
chemotherapy or radiotherapy involved, and the patient's general health condition.

Keywords: PDW, laryngeal cancer, patients.