EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

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 ICV - 79.57

Abstract

PREVENTION OF SEVOFLURANE RELATED EMERGENCE AGITATION IN CHILDREN UNDERGOING COCHLEAR IMPLANT: A COMPARISON OF NALBUPHINE AND PROPOFOL

*Dr. Sameer Goyal, Dr. Prakash Chandra Audichya, Dr. Komal Soni, Dr. Jyoti Petkar, Dr. R.K. Singh

ABSTRACT

Background: Aim of present study was to compare the effect of single dose of propofol or nalbuphine prior to termination of sevoflurane based anesthesia on incidence and severity of EA in children. Methods: Thirty children, ASA I-II, 18 months to 8 years old undergoing cochlear implant surgery under sevoflurane based anesthesia were enrolled in the study. Children were randomly allocated to one of three equal groups: Group C received 10 ml saline 0.9%, Group P received propofol 1 mg/kg and group N received nalbuphine 0.1 mg/kg-1. Study drugs were administered 5 min before the end of surgery. In post anesthesia care unit (PACU), incidence of EA was assessed with Aonos four point scale and severity of EA was assessed with pediatric anesthesia emergence delirium scale upon admission (T0), after 5 min (T5), 15 min (T15) and 30 min (T30). Extubation time, emergence time and duration of PACU stay were assessed. Results: Incidence and severity of EA were lower in group P and group N compared to group C at T0, T5 and T15 . Incidence and severity of EA in group P were higher than group N at same times. Incidence and severity of EA decreased significantly over time in all groups. The modified Children's Hospital of Eastern Ontario Pain Scale was lower in group N compared to group P and group C. Conclusions: Although statistically not significant but Nalbuphine 0.1mg/kg1 was more effective than propofol 1 mg/kg in decreasing incidence and severity of EA, when administered 5 min before end of surgery in children undergoing cochlear implant surgery under sevoflurane anesthesia.

Keywords: Children, nalbuphine, emergence agitation, propofol, sevoflurane.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )