EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

A STUDY TO EVALUATE THE EFFECT OF GATIFLOXACIN ON BLOOD SUGAR LEVELS IN DIABETIC AND NON DIABETIC RABBITS – A CHRONIC PROSPECTIVE STUDY

Akash Khobragade*, Mrityunjay Khopkar, Sadiq Patel, Snehal Kosale and Kiran Paripelli

ABSTRACT

Introduction: The aim of the study is to evaluate the effects of gatifloxacin alone and in combination with glyburide on blood sugar levels in non-diabetic and alloxan induced rabbits. Methods: 24 hrs fasting animal‘s blood was collected for baseline investigations. After blood collection, alloxan was induced intravenously in 32 out of 40 rabbits. On day 2 FBS was repeated and other investigations were repeated on day 3. FBS and S. Insulin were repeated on day 7 of treatment. On day 14 of treatment (end day of treatment) the above mentioned investigations were repeated again. Results: After alloxan induction, FBS levels of gr-I, gr-II, gr-III, gr-IV at baseline were 93.63, 94.13, 93.88, 93.13 mg/dl, 24 hours after alloxan induction were 220.63, 220.86, 220.87, 220.88 mg/dl, 48 hours after alloxan induction were 221.13, 221, 222, 221 mg/dl. S.Insulin levels for the groups for baseline were 3.84, 3.78, 3.74, 3.79 mg/dl; 48 hours after alloxan were 1.80, 1.81, 1.80, 1.83 mg/dl. FBS levels after 2 weeks of Gatifloxacin medication in gr-III and gr V for baseline were 222, 93.63 mg/dl, at 1week were 220.75, 93.25mg/dl, at 2 weeks were 220.38, 93.38 mg/dl. S. Insulin levels for both above groups and after 2 weeks of gatifloxacin medication for baseline were 1.80, 3.76 mg/dl, at 1 week 1.82, 3.77mg/dl, at 2 weeks 1.84, 3.78 mg/dl. Conclusion: Gatifloxacin, at therapeutic doses, had no effect on blood glucose levels or insulin levels, even on prolonged intake, both in diabetics and non-diabetics. Concurrent administration of gatifloxacin and glyburide did not significantly reduce blood glucose concentrations, than when glyburide is administered alone, in diabetics. Gatifloxacin should be avoided as an outpatient or as an over the counter drug. It may, be used on an inpatient basis as the recipient is under medical observation.

Keywords: Diabetes Mellitus, Alloxan, Gatifloxacin, Glyburide, FBS, Insulin.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia