EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

ANTIARRHYTHMIC EFFECT OF THE LEAF VOLATILE OIL OF ELETTARIA CARDAMOMUM MATON. ON THE HEART OF Daphnia magna

N. Subbulekshmi*, Dr. M.Malathi, M.D., DGO. Dr. K. Periyanayagam, B. Sugithra, S. Indumathi, T. Umapoorani

ABSTRACT

Objective: To prescreen the in vivo cardioprotective activity of the leaves of Elettaria cardamomum. Maton Family Zingeberaceae using the model organism Daphnia magna along with preliminary acute toxicity assessment. Method: Thecardioprotective effect of the volatile oil of the leaves of E.cardamomumin vivo on the lactose induced arrhythmic heart of the cladocerans D. magna (Water flea) a novel model system for studying effects of agonists and toxins on cell signalling and ion channels in situwas evaluated. Initially GCMS of the isolated VO, acute toxicity assessment were determined. Results: GC-MS profile of the VO showed the presence of 4-terpineol, 1:8 cineol, α-terpinolene, α-Tujene, α-pinene, sabinene, linalool, α-terpineol, p-cymene, α-terpinene, endbornyl acetate. Normal mean heart beat of the D.magnaat 20±2°C was found to be 180.1± 1.0 beats/min. Arrhythmia was induced by lactose (50mM) in the bathing medium. The VO of the leaves of E.cardamomum(0.5, 1.0, 1.5, 2.0μl/ml) prevented the lactose induced arrhythmia in dose dependent manner. Previous assessment of toxicity showed LC50 5μl/ml. Conclusion: E.cardamomum. (cardamom) has long been recognized and economically is of appreciable importance as a spice. This study indicates that the VO of the leaves of E.cardamomum possesses potential cardio protective activity on the lactose induced arrhythmia of the Daphnia heart without any toxicity and mortality. It is assumed that this may be due to the presence of terpenes in the VO.Further investigation requires confirming this activity.

Keywords: Elettariacardamomum, Zingeberaceae, Cardioprotective action, Daphnia magna, Volatile oil.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )