FORMULATION & EVALUATION OF TRANSDERMAL PATCH OF ACETOHEXAMIDE
Ganju Eisha* and Ganju Kuldeep
The aim of the present investigation was to prepare acetohexamide transdermal patches by solvent casting technique using the HPMC and PVP. The systems were evaluated for various in- vitro parameters (Thickness, Folding endurance, Moisture content, Moisture uptake, Flatness, Water vapor transmission rate etc). In- vitro permeation studies were performed by using Franz diffusion cells. Variations in drug permeation profile were observed among various formulations. From all the formulations, formulation P3 was selected as the best formulation and formulation was stable for period of 90 days stability study.
Keywords: Transdermal drug delivery, Matrix patch, Membrane controlled Patch, acetohexamide, HPMC, PVP, In vitro skin permeation studies.
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