HISTOPATHOLOGICAL STUDY OF CARCINOMA OF THE PROSTATE
Dr.Harsh Kumar Baid, Dr.Vanita Kumar, Dr.Neelu Gupta, Dr. DharmChand Kothari*
ABSTRACT
Adenocarcinoma is the most common malignancy of the prostate and
one of the leading causes of death in males. Prostate cancer accounts
for 14% of cancer deaths, the second highest in men after lung cancer.
Serum PSA, Fine Needle Aspiration cytology (FNAC) and core biopsy
integration of these methods into diagnostic triad has enhanced the
early detection of prostate cancer at early stage which is curable.
Gleason’s grading and serum PSA level are important markers for
estimating prognosis of prostatic cancer. Methods and Material: 70 cases of prostatic
malignancy, admitted to department of urology were included in this study. Serum PSA level
of prostate was record in all cases. Needle Core Biopsy and TURP specimens were examined
for histopathological diagnosis and Gleason grading was done according to Gleason grading
system where ever possible. Results: In the present study 70 cases of prostatic carcinoma
were study out of which 68 cases were adenocarcinoma (63 cases were conventional
adenocarcinoma and 5 cases were adenocarcinoma foamy cell variant) and 2 cases were
transitional cell carcinoma. Prostatic carcinoma was most common in 7th decade. Maximum
No. of patient has serum PSA level >10ng/ml (92.85% cases of carcinoma). The sensitivity
(92.3%) were maximum for serum PSA level > 4 ng/ml for prostatic carcinoma. Transitional
cell carcinoma (2.9%) is a less common type of carcinoma other than adenocarcinoma which
occur primarly in prostate. According to Gleason grading system maximum no. of cases of adenocarcinoma (65.71%) were found moderately differentiated adenocarcinoma which have
Gleason score 5-7. Followed by poorly differentiated adenocarcinoma (28.6%) which have
Gleason score 8-10. 2 cases were found well differentiated adenocarcinoma (2.9%) which
have Gleason score 2-4. Conclusion: Integration of DRE serum PSA level and Biopsy is the
best method for detection of Prostate carcinoma. All prostate carcinoma should be graded by
Gleason grading system to know the prognosis of carcinoma.
Keywords: Prostate adenocarcinoma, Gleason grading, PSA level, Transitional cell carcinoma.
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