( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57



Niggula Praveen Kumar*, J. E. Rachel Nivedita, V. Arun Reddy, Togari Manoj Kumar and Gatadi Srikanth



Quinoline derivatives are a class of compounds with a wide range of biological activities, including antimicrobial
properties. The development of novel antimicrobial agents is essential to combat the growing threat of antibiotic
resistance. In this study, we synthesized a series of quinoline derivatives and their Schiff bases, and evaluated their
antimicrobial activities against a panel of Gram-positive and Gram-negative bacteria, as well as fungi. The
quinoline derivatives were synthesized through the reaction of quinoline-2-carbaldehyde with various amines,
including aniline, p-anisidine, and o-phenylenediamine. The resulting Schiff bases were characterized by FTIR,
NMR, and mass spectroscopy. The antimicrobial activities of the synthesized compounds were evaluated using the
disc diffusion method and minimum inhibitory concentration (MIC) assays. The results show that the quinoline
derivatives and their Schiff bases exhibited significant antimicrobial activity against all tested microorganisms,
with MIC values ranging from 0.5 to 64 μg/mL. The Schiff bases showed improved antimicrobial activity
compared to their parent quinoline derivatives, with some exhibiting MIC values as low as 0.5 μg/mL. The most
active compounds were found to be those containing the p-anisidine and o-phenylenediamine moieties. The results
of this study demonstrate the potential of quinoline derivatives and their Schiff bases as novel antimicrobial agents.
The synthesized compounds may be useful in the development of new antibiotics to combat the growing threat of
antibiotic resistance. Further studies are needed to investigate the mechanism of action of these compounds and to
evaluate their safety and efficacy in animal models.

Keywords: Schff bases, Quinoline derivatives, QSAR, Antimicrobial drugs.

[Full Text Article] [Download Certificate]


  All Since 2019
 Citation  3086  2560
 h-index  18  17
 i10-index  64  44



  • New Issue Published

    Its Our pleasure to inform you that, EJPMR 1 July 2024 Issue has been Published, Kindly check it on


    JULY 2024 issue has been successfully launched on JULY 2024.

  • EJPMR New Impact Factor

    EJPMR Impact Factor has been Increased to 7.065 for Year 2024.

  • Index Copernicus Value

    EJPMR Received Index Copernicus Value 79.57, due to High Quality Publication in EJPMR at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.


  • Article Invited for Publication

    Article are invited for publication in EJPMR Coming Issue

Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia