EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

A CROSS SECTIONAL STUDY ON PREVALENCE OF ELEVATED LIVER ENZYMES AND THEIR ASSOCIATION WITH TYPE 2 DIABETES MELLITUS

Dr. Shahanaz Akter*, Nowrose Jahan, Dr. Farzana Afroze, Dr. Sumi Dey, Dr. Muhammad Ismail Hasan,
Afsana Akhter

.

ABSTRACT

Background: Diabetes mellitus represents a significant global health challenge, with Type 2 Diabetes Mellitus
(T2DM) being particularly prevalent and on the rise, especially in low and middle-income countries. Liver
enzymes, including aspartate aminotransferase (AST), alanine aminotransferase (ALT), and γ-glutamyltransferase
(GGT), are crucial indicators of liver health and metabolism, with elevated levels often associated with diabetes.
Despite the public health importance of this relationship, there's a dearth of comprehensive research, particularly in
Bangladesh. This study aimed to bridge this gap by evaluating liver enzyme levels and their correlation with
T2DM. Objective: The objective of this study was to assess the frequency of elevated liver enzymes and their
association with T2DM. Method: A cross-sectional study was conducted in Sir Salimullah Medical College
Hospital, Dhaka from May to November 2023. The study included 192 participants with T2DM and an equal
number of control participants without diabetes. Liver enzymes (AST, ALT, and GGT) were measured, and
statistical analysis was performed using independent t-tests. Results: The study found that persons with Type 2
Diabetes Mellitus (T2DM) had significantly higher levels of Aspartate Aminotransferase (AST) and Alanine
Aminotransferase (ALT) compared to the control group (p < 0.001). Nevertheless, there was no substantial
disparity in GGT levels seen between the two groups (p = 0.065). Individuals with T2DM had a considerably
higher mean fasting blood glucose level compared to controls (p < 0.001). The liver function test results of the
participants with type 2 diabetes mellitus (T2DM) were substantially higher compared to the control group. The
serum alanine aminotransferase (ALT) level was 46.06 ± 22.38 IU/L and the serum aspartate aminotransferase
(AST) level was 42.94 ± 19.08 IU/L, with a p-value of less than 0.001. However, there was no significant
association between the gamma-glutamyl transferase (GGT) level in both study groups, with a p-value of 0.065.
Conclusion: Elevated levels of AST and ALT are common in individuals with T2DM, indicating potential liver
dysfunction. Liver enzyme testing may serve as a valuable tool in the assessment and management of diabetesrelated
complications.

Keywords: Type 2 Diabetes Mellitus, Liver enzymes, aspartate aminotransferase (AST), alanine aminotransferase (ALT).


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia