SYNTHESIS AND BIOLOGICAL EVALUATION OF MORPHOLINE AND SALICYLAMIDE NUCLEUS BASED DERIVATIVES

Loganathan Velupillai, Prashant P Dixit, M.S. Shingare & D.V. Mane*

ABSTRACT

Morpholine backbone is essential in different pharmacologically active synthetic compounds. Present work is synthesis of novel morpholine and salicylamide nucleus based compounds such as 3-amino-2, 2- dimethylpropyl 2-(2-(2-morpholinoethylcarbomyl)phenoxy)acetate and their derivatives (6 L – 6 R). The compounds were synthesized in multistep reaction with more efficient process. Starting materials are commercially available and is also available from Sigma-Aldrich. The chemical structures of the synthesized compounds were confirmed by means of 1HNMR and mass spectral data. High yield and high purity indicates lack of side reaction and by product. The synthesized compounds were then examined for their antibacterial and antifungal activities. Some of them were found to possess good antibacterial and antifungal activity.

Keywords: Morpholine, Salicylamide, Salicylic acid, Antibacterial, Antifungal Activity.