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European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57



Dr. Shashi Kumar, *Dr. Gayatri Ganu, Dr. Dheeraj Nagore, Susheel Joshi and Dr. Vaishali Undale



Introduction: Osteoarthritis (OA) is a degenerative joint disorder hallmarked by progressive cartilage loss,
osteophyte formation, subchondral bone sclerosis, and synovial inflammation. These pathologic processes
ultimately manifest as joint pain, structural deformities, and functional impairment. This preclinical study aimed to
evaluate the anti-arthritic activity and chondrocyte regeneration potential of nutritional formula supplements in a
monosodium iodoacetate-induced (MIA) rat model of osteoarthritis. Materials & Methods: In the preclinical
study thirty-two Wistar rats were randomly divided into four groups, 8 rats in each group. Rats from sham control
(SC) and disease control (DC) groups received oral Carboxymethyl cellulose (CMC) 1%, while oral Indomethacin
(2 mg/ kg) in 1% CMC was administered to rats from PC group. The test group received an oral nutritional formula
(218.24 mg/kg) in 1% CMC for 28 days. Results: Preclinical study of nutritional formula demonstrated reduced
swelling and improved mobility within 7 days of treatment. By day 28, significant anti-inflammatory effects were
observed, evidenced by lowered COMP, MMP-13, and TNF-alpha levels. Radiological and histopathological
analysis supported these findings, indicating less degeneration in the nutritional formula group compared to
controls, suggesting potential for regeneration and chondroprotection. Conclusion: The preclinical findings
conclude that nutritional formula exhibits multifaceted benefits, including anti-arthritic and anti-inflammatory
effects, offering a promising alternative for knee osteoarthritis management. Additionally, nutritional formula
shows promise in promoting joint cartilage regeneration, although further investigations are warranted to assess its
chondrocyte protective effect in humans.

Keywords: Knee osteoarthritis, Anti-inflammatory, Cartilage repair, Chondrocyte regeneration, Monoiodoacetate.

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia