EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

HESPERETIN ENCAPSULATED PLGA NANOPARTICLES: SYNTHESIS, CHARACTERIZATION AND EVALUATION OF ITS IN-VITRO ANTIOXIDANT POTENTIAL AS WELL AS IN VIVO TOXICITY IN SWISS ALBINO MICE

Dibyendu Giri, Angsuman Das Chaudhuri, Anirban Majumder, Ahana Sinha, Subhabrata Das, Tanmoy Maity, Aranya Ghosh, Gouri Karan, Mrinmoyee Modak and Dr. Sujata Maiti Choudhury*

ABSTRACT

Hesperetin (HSP), a bioflavonoid, exhibits wide range of biological and pharmacological activities. It could be used as a prospective therapeutic agent by increasing its bioavailability and hydrophilicity. The aim of the current work is to fabricate hesperetin encapsulated PLGA nanoparticles and to investigate its toxicological effects as well as to assess its in-vitro antioxidant capacity. To address these objectives an environmental-friendly HSP loaded poly (lactic-co-glycolic acid) (PLGA) nanoparticles (PLGA-HSP NPs) was synthesized. DLS, UV-Vis studies were used to evaluate the properties of nano-hesperetin. The sub-acute toxicity of PLGA-HSP NPs was evaluated at different dose levels in Swiss albino mice after 28-days intraperitoneal administration. Hepatic and renal biomarkers of PLGA-HSP NPs treated mice were not altered significantly compared to free drug and control animals. The effects of nano-hesperetin as an antioxidant agent were also investigated. When PLGA-HSP NPs were compared to conventional ascorbic acid, they exhibited significantly greater free radicals scavenging action than HSP. In-vitro nitric oxide, superoxide, lipid peroxidation and hypochlorous acid scavenging tests revealed the potent concentration-dependent scavenging ability of PLGA-HSP NPs. In conclusion, it may be stated that PLGA nanoparticles encapsulated hesperetin is a non-toxic nano-conjugate and possesses a potent in-vitro antioxidant efficacy.

Keywords: Hesperetin; PLGA; Toxicity study; In vitro antioxidant activity; Swiss albino mice.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia