EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

EXPLORING THE THERAPEUTIC POTENTIAL OF ROSUVASTATIN IN WOUND HEALING: A MOLECULAR DOCKING PERSPECTIVE

Dhilip S., Dr. Pandian C.* and Dr. Abdul Hasan Sathali A.

ABSTRACT

Rosuvastatin, a synthetic HMG-CoA reductase inhibitor, has been shown in experiments to be beneficial in wound healing because it reverses the action of wound healing inhibitors like farnesyl pyrophosphate (FPP) and increases microvascular and endothelial activity, thereby improving wound healing processes. The work used molecular docking to analyze the interactions between rosuvastatin and nine wound healing-associated proteins (FGFR1, TGFR-β 1, VEGFR2 & 3, MMP9 & 12, ERB-β1, PDGFR, and RAGE). The molecular docking simulations were run with PyRx software, which predicted the binding relationships between rosuvastatin and the target proteins. Rosuvastatin's binding energies with each protein were computed to establish their affinity for the ligand. The docking studies showed that rosuvastatin had favourable binding interactions with all nine proteins, indicating that it has the ability to modulate their activity. MMP 9 proteins had the greatest binding energy among the target proteins, followed by TGFR-β1, ERB-β1, MMP-12, VEGFR 2, PDGFR, VEGFR 3, RAGE, and FGFR 1 in decreasing order of binding energies. In this study, we looked at the impact of Rosuvastatin (RSV) on nine proteins linked with poor wound healing. These nine proteins are linked and contribute to poor wound healing. The effect of RSV on these proteins was established utilizing molecular docking experiments. The PyRx application was used to conduct docking simulations between RC and the nine proteins related to poor wound healing. Visualizing the binding connections between rosuvastatin and the target proteins revealed molecular interactions and probable mechanisms of action. The findings highlight the rosuvastatin's therapeutic potential in targeting particular proteins involved in wound healing impairment, establishing it as a viable treatment for chronic wounds.

Keywords: Rosuvastatin, molecular docking, wound healing FGFR1, TGFR-? 1,VEGFR2 & 3 , MMP9 & 12, ERB-?1, PDGFR and RAGE.


[Full Text Article] [Download Certificate]

Citation

  All Since 2019
 Citation  3086  2560
 h-index  18  17
 i10-index  64  44

INDEXING

NEWS & UPDATION

  • New Issue Published

    Its Our pleasure to inform you that, EJPMR 1 July 2024 Issue has been Published, Kindly check it on https://www.ejpmr.com/issue

  • EJPMR: JULY ISSUE PUBLISHED

    JULY 2024 issue has been successfully launched on JULY 2024.

  • EJPMR New Impact Factor

    EJPMR Impact Factor has been Increased to 7.065 for Year 2024.

  • Index Copernicus Value

    EJPMR Received Index Copernicus Value 79.57, due to High Quality Publication in EJPMR at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Article are invited for publication in EJPMR Coming Issue

Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia